Research has looked into a virus called SV40 (the SV stands for 'simian virus'). In people who have been exposed to asbestos, some studies have shown that contact with the SV40 virus makes it more likely that they will develop mesothelioma. So SV40 is thought of as a possible 'co-factor' for mesothelioma development. Some people in certain parts of the former USSR were exposed to SV40 virus by contaminated polio vaccines in the 1970's. http://www.cancerhelp.org.uk
One highly contentious issue is the role of simian virus 40 (SV40) in the development of mesothelioma tumors. Animal experiments have established that SV40 is a potent tumor inducing virus, however, clinical studies still have not conclusively linked SV40 to human mesothelioma cases. Many studies and publications have demonstrated the presence of SV40 in multiple tumors including malignant mesothelioma. .
There is some evidence, however, that the SV40 presence in the samples may be due to pervasive laboratory contamination. The source of this contamination was the original monkey cell cultures used as a medium in which to grow smallpox vaccines. The SV40 remnants were felt to be benign and were therefore ignored by laboratories. it was only later that the tentative connection to cancer was noted.
Animal models and in vitro studies with human mesothelial cells when, exposed to a attenuated strain of SV 40 suggest that they may act as co carcinogens. When exposed to this attenuated strain of SV40 alone no malignant mesothelioma was observed, When exposed to both the attenuated strain and asbestos mesothelioma developed. It therefore it can be assumed that SV 40 is not directly responsible for the development of mesothelioma but might have a synergistic role when coupled with asbestos exposure. Laboratory work in this area continues and the role of SV40 in mesothelioma remains to clearly defined. http://www.curemeso.org
There is some evidence, however, that the SV40 presence in the samples may be due to pervasive laboratory contamination. The source of this contamination was the original monkey cell cultures used as a medium in which to grow smallpox vaccines. The SV40 remnants were felt to be benign and were therefore ignored by laboratories. it was only later that the tentative connection to cancer was noted.
Animal models and in vitro studies with human mesothelial cells when, exposed to a attenuated strain of SV 40 suggest that they may act as co carcinogens. When exposed to this attenuated strain of SV40 alone no malignant mesothelioma was observed, When exposed to both the attenuated strain and asbestos mesothelioma developed. It therefore it can be assumed that SV 40 is not directly responsible for the development of mesothelioma but might have a synergistic role when coupled with asbestos exposure. Laboratory work in this area continues and the role of SV40 in mesothelioma remains to clearly defined. http://www.curemeso.org
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